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권동일 학생의 Nature Communications 논문 최종 accept [2022.02.24]

관리자 │ 2022-02-24

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권동일 학생의 "Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival" 논문이 

Nature Communications에 최종 accept 되었습니다. 모두 축하해주세요~!!!!


주저자: 권동일 / 공동저자: 강연우, 이승우


[Abstract]

Increased serum levels of immunoglobulin E (IgE) is a risk factor for various diseases, including allergy and anaphylaxis. However, the source and ontogeny of B cells producing IgE under steady state conditions are not well defined. Here, we show plasma cells that develop in the thymus and potently secrete IgE and other immunoglobulins, including IgM, IgA, and IgG. The development of these IgE-secreting plasma cells are induced by IL-4 produced by invariant Natural Killer T cells, independent of CD1d-mediated interaction. Single-cell transcriptomics suggest the developmental landscape of thymic B cells, and the thymus supports development of transitional, mature and memory B cells in addition to plasma cells. Furthermore, thymic plasma cells produce polyclonal antibodies without somatic hypermutation, indicating they develop via the extra-follicular pathway. Physiologically, thymic-derived IgEs increase the number of mast cells in the gut and skin, which correlates with the severity of anaphylaxis. Collectively, we define the ontogeny of thymic plasma cells and show that steady-state thymus-derived IgEs regulate mast cell homeostasis, opening up new avenues for studying the genetic causes of allergic disorders. 


[Summary Figure]

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